The tumor microenvironment

by Rebecca G. Bagley

Publisher: Springer in New York

Written in English
Published: Pages: 767 Downloads: 715
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Subjects:

  • Physiopathology,
  • Pathology,
  • Neoplasms,
  • Neoplastic Stem Cells

About the Edition

This book will explore the many biological and physical aspects of the tumor microenvironment. The book will include chapters on the various cells that influence tumor growth and function as well as the cell-associated and soluble proteins that can promote invasion and metastasis. Several chapters will describe endothelial cells and pericytes that form tumor vasculature. Insights on the role of progenitor and stem cells will be included. The contribution of the supporting stroma will be addressed in addition to cell-cell signaling and cell-matrix interactions. Additional chapters will describe the influence of infiltrating cells of the immune system on tumor growth.

Edition Notes

StatementRebecca G. Bagley, editor
SeriesCancer drug discovery and development, Cancer drug discovery and development
The Physical Object
Paginationxviii, 767 p. :
Number of Pages767
ID Numbers
Open LibraryOL25045567M
ISBN 101441966145
ISBN 109781441966148
LC Control Number2010934382
OCLC/WorldCa646115129

  Impact of the tumor microenvironment on the control of cancer. Targeting the tumor microenvironment. Summary. 2 Establishing the Tumor Microenvironment (Allison S. Betof and Mark W. Dewhirst). Introduction. From cancerous cells to a tumor. A tumor is more than cancer cells and fibroblasts. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-1, IL-8, IL, IL signaling, and more. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins Part A updates us on what we know about various aspects of the tumor. The metastasis and recurrence of tumors are the main reasons for cancer death. In this work, a promising therapy for tumor treatment that can eliminate primary tumors and prevent tumor relapses is introduced by combining chemotherapy, photothermal therapy (PTT) . Keywords:Cancer metabolism, glutamine, sarcosine, aspartate, methionine, metastasis. Abstract:Metabolic changes driven by the hostile tumor microenvironment surrounding cancer cells and effect of these changes on tumorigenesis and metastatic potential have been known for a long time. The usual point of interest is glucose and changes in its.

The interactions between tumor cells and the non-malignant stromal and immune cells that make up the tumor microenvironment (TME) are critical to the pathophysiology of cancer. The tumor microenvironment refers to the network of cells and structures that surround a tumor, including stroma, the connective cells and tissue, and immune regulatory cells, such as Tregs. Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer . Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes.

The Tumor Microenvironment Network, or TMEN, was a program launched by the NCI in (RFA CA) and reissued in (RFA CA) that funded research in basic cancer biology to study the mechanisms of tumor-host interactions in human initiative funded 20 collaborative Center grants across the country and 10 collaborative U01 grants that brought together a TMEN key. A comprehensive understanding of the tumor microenvironment, including stromal composition, cell-cell and cell-matrix interactions, and abnormal physiology, as well as cellular characteristics of heterogenous tumors is key to elucidating the complexities of cancer. Efficient cancer vaccines not only require the co-delivery of potent antigens and highly immunostimulatory adjuvants to initiate robust tumor-specific host immune response but also solve the spatiotemporal consistency of host immunity and tumor microenvironment (TME) immunomodulation. Here, we designed a biomaterials-based strategy for converting tumor-derived antigenic . comprise tumor the microenvironment (TME). he T TME consists of extracellular matrix (ECM) as well as myofibroblasts and cellular players, such as fibroblasts, neuroendocrine (NE) cells, adipose cells, immune-inflammatory cells, and the blood and lymphatic vascular networks [32]. Furthermore, TME.

The tumor microenvironment by Rebecca G. Bagley Download PDF EPUB FB2

About this book The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. The first edition of The Tumor Microenvironment is intended to give a current perspective on the role of the tumor microenvironment in malignant progression and detail strategies for novel therapies directed towards the cellular matrix.

This book explores the many biological and physiological aspects of the tumor as a tissue and includes Format: Hardcover. The first edition of The Tumor Microenvironment is intended to give a current perspective on the role of the tumor microenvironment in malignant progression and detail strategies for novel therapies directed towards the cellular matrix.

This book explores the many biological and physiological aspects of the tumor as a tissue and includes. From Book 1: Traditionally, the interplay between cancer cells and host immunity has been studied systemically.

Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. This book covers core and emerging in vitro and in vivo protocols used to study how various components of the tumor microenvironment are established and subsequently interact with tumor.

Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research in the field. Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment.

Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and : Springer International Publishing.

Tumor Microenvironment: The Role of Chemokines – Part A (1st ed. ) (Advances in Experimental Medicine and Biology #) View larger image. By: Alexander Birbrair.

Synopsis Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of Author: Alexander Birbrair.

Introduction Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. About the authors Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment.

In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed.

The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management.

Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer.

Cross-talk in the tumor microenvironment. A, The impact of inflammatory or tumor-suppressive immune cells on tumor cells in the TME. The bold arrows show the impact that immune cells ideally have on tumor cells (TC).

The interactions between NKTs, DCs, T cells, neutrophils, ILCs, M φ, and NK cells and tumor cells are depicted. Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment.

Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-1, IL Author: Alexander Birbrair.

Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironment, and to support clinical decisions taking into consideration its specificities. Tumor progression is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic Book Edition: 1.

Tumor Microenvironment: Extracellular Matrix Components Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development.

Nevertheless, the commonly held view is that changes in tumor microenvironment are "soft-wired", i.e. epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu.

The Tumor Microenvironment PDF – Methods and Protocols The Tumor Microenvironment PDF Free Download, The Tumor Microenvironment PDF, The Tumor Microenvironment Ebook Content This book covers core and emerging in vitro and in vivo protocols used to study how various components of the tumor microenvironment are established and subsequently interact with tumor cells to.

In book: Tumor Microenvironment (pp) Authors: Cassandra R Goulet. The tumor microenvironment is a dynamic cellular milieu interacting with cancer cells, thus promoting tumor growth, proliferation, angiogenesis, invasiveness, and metastasis. In tumor microenvironments, the motility and immune functions of DCs are impaired, but the mechanisms are largely unknown.

This book offers researchers a comprehensive and deep insight into the biophysical characteristics of DCs and may also help to improve the efficiency of anti-tumor therapy based on DCs. GET IT FREE HERE. This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment.

Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. (). Tumor Microenvironment and the Response to Anticancer Therapy.

Cancer Biology & Therapy: Vol. 1, No. 5, pp. The composition of the tumor microenvironment varies between tumor types, but hallmark features include immune cells, stromal cells, blood vessels, and extracellular matrix.

It is believed that the “tumor microenvironment is not just a silent bystander, but rather an active promoter of cancer progression” (Truffi et al., ).Author: Nicole M. Anderson, M. Celeste Simon. Nanomedicine, acting as the magic bullet, is capable of combining immunotherapy with other treatments to reverse a cold tumor (immune depletion) into a hot tumor.

However, how to comprehensively inhibit the immunosuppressive tumor microenvironment (TME) remains a major challenge for immunotherapy to achieve the maximum benefits. Thus, a strategy that can simultaneously increase the recruitment.

McKinley Place NE Minneapolis, MN USA. TEL Toll-free FAX The tumor microenvironment (TME) is the environment around a tumor, including the surrounding blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix (ECM).

The tumor and the surrounding microenvironment are closely related and interact constantly. A tumor microenvironment contains various noncancerous cells including adipocytes, fibroblasts, immune and inflammatory cells, neuroendocrine cells, pericytes, vascular and lymphatic endothelial cells, and the extracellular matrix that surrounds cancerous cells.

In the tumor microenvironment, cancer cells interact and cross talk with noncancerous cells and orchestrate Cited by: 2. Tumors appear as heterogeneous tissues that consist of tumor cells surrounding by a tumor microenvironment (TME).

TME is a complex network composed of extracellular matrix (ECM), stromal cells, and immune/inflammatory cells that drive cancer cells fate from invasion to intravasation and metastasis.

The stromal-inflammatory interface represents a dynamic space, in which exchange. Abstract In addition to malignant cells, the tumor microenvironment also includes nonmalignant cells, secreted proteins, and blood vessels that surround and support the growth of the tumor.

1. Am Soc Clin Oncol Educ Book. Jan; doi: /EDBK_ Epub May Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies.Conference Cochairs. Yibin Kang, Princeton University, Princeton, New Jersey Sheila A. Stewart, Washington University School of Medicine, St.

Louis, Missouri Valerie M. Weaver, University of California San Francisco, San Francisco, California. The complexity and functional contribution of the tumor microenvironment in cancer progression continues to expand at the cellular, organ and systemic.Tumor microenvironment (TME)-mediated nanocatalytic therapy has been deemed as a promising strategy for improving the effectiveness of tumor therapy.

Herein, we construct a glucose-responsive cascaded nanocatalytic reactor ([email protected] NCR) which co-loads glucose oxidase (GOx) and chemotherapeutic drug tirapaz.